KMID : 1195620190120030273
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Clinical and Experimental Otorhinolaryngology 2019 Volume.12 No. 3 p.273 ~ p.278
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Serum Vitamin D and Long-term Outcomes of Benign Paroxysmal Positional Vertigo
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Rhim Gu-Il
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Abstract
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Objectives: The purpose of the present study was to examine the effect of serum vitamin D concentrations on the longterm recurrence rates of benign paroxysmal positional vertigo (BPPV) patients.
Methods: The present study was conducted with patients diagnosed with BPPV from June 2014 to April 2016. Whether the patients¡¯ sex, age, types and locations of semicircular canals, diabetes, hypertension, hyperlipidemia, and vitamin D concentrations affect their recurrence rates was examined using Pearson chi-square tests, independent samples t-tests and Cox proportional hazards regression analyses. The effects of vitamin D concentrations on long-term recurrence rates were examined using Kaplan-Meier estimates and log-rank tests.
Results: The recurrence rates obtained with Kaplan-Meier estimates were 18% and 50% at 12 months and 24 months, respectively. When the patients were divided into groups with vitamin D concentrations of <10 ng/mL and ¡Ã10 ng/mL and the recurrence rates of the groups were compared, the difference was statistically significant (P=0.040). In addition, when the patients were divided into groups with vitamin D concentrations of <15 ng/mL and ¡Ã15 ng/mL and the recurrence rates of the groups were compared, the difference was statistically quite significant (P=0.017). In a Cox regression model, variables such as age, sex, the types and locations of semicircular canals, hypertension, diabetes, hyperlipidemia, and 25-hydroxy vitamin D did not significantly affect recurrence.
Conclusion: The present study investigated the recurrence rates of BPPV in patients for a long time without limiting the sex, age, or locations of semicircular canals and it could be seen that serum vitamin D concentrations significantly affected the recurrence of BPPV.
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KEYWORD
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Benign Paroxysmal Positional Vertigo, Vitamin D Deficiency, Recurrence, Kaplan-Meier Estimate
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